Nanovis portfolio of implant nanosurfaces, nanostructured biomaterials and bone growth peptides allows us to design and manufacture implant nanosurfaces, implantable scaffolds or injectable biomaterials, with tissue growth properties that are superior to conventional materials or therapeutics. Nanovis is advancing important nanostructured biomaterial and nanosurfaced implant programs alone and in conjunction with strategic partners. Due to confidentiality and intellectual property factors only a portion of Nanovis’ technology is described here.

Nanovis nanostructured biomaterials are designed to act as highly effective tissue scaffolds that customizable resorption profiles and capability for localized drug delivery. Nanovis uses the tissue integration and inflammation reduction properties of nanomaterials to develop biomaterial products with important advantages over conventional biomaterials. Nanovis is currently developing nanostructured biomaterials using novel nanostructured polymers and nanoscale ceramics as well as novel self assembling helical rosette nanotubes

Helical Rosette Nanotubes

A highly novel, patented chemistry invented by Hicham Feniri and collaborators, helical rosette nanotubes have shown promise for an important set of benefits that impact a wide range of potential product applications. Nanovis is evaluating helical rosette nanotube conformations for a broad set of application.

Nanostructured polymers and polymer/ceramic based biomaterials materials. Nanovis is developing these novel biomaterials  Nanovis is pursuing programs using these materials for a wide range of applications related to tissue repair.

Nanovis’ biomaterial programs are expected to provide needed clinical solutions to orthopedic surgeons, spine surgeons, radiologists, and general surgeons performing restorative or repair surgeries in a wide range of tissues.

Nanovis has acquired and is developing an important set of bone growth peptides. These peptides are suitable for delivery as a combination product with our nanostructured biomaterials and are designed to provide a complementary mechanism of action. Nanovis is pursuing nanostructured biomaterial/bone growth peptide programs primarily in the orthopedic fields.

Polymers, Nanovis has nanosurfaced a wide range of polymers while leaving Surface chemistry of the polymer unchanged and improving the tisue integration.

Nanovis tested these polymers across a wide range of soft tissue, cartaliginous and bone cell types and has seen consistent improvements in cellular responses to our nanosurfaces. For example, In vitro our Nanosurfaces significantly improved fibroblast proliferation on polypropylene hernia meshes while reducing macrophage proliferation:

Nanovis’ work with polymer Nanosurfaces has important implications for clincial outcomes in soft tissue repair and cardiovascular surgery.

While our metal Implant Nanosurfaces have shown important improvements in bone ingrowth in vivo after 28 days of implantation:

Nanovis Nanosurface intellectual property, expertise and experience covers a wide array of polymer, metal and ceramic implant materials. Nanovis, frequently in collaboration with strategic relationship partners is developing implant nanosurfaces to improve the clinical outcomes for dental, orthopedic, soft tissue repair, urogential, cardiovascular and neurosurgical implants.

Nanovis technology allows us to use design nanomaterials, as implant surfaces, implantable scaffolds or injectable biomaterials, with tissue growth properties that are superior to conventional materials and then attach bone growth stimulating peptides to further accelerate the tissue regeneration process. Nanovis’ combination of complementary technology is designed to provide tissue regeneration superior to approaches using conventional materials or therapeutics alone or in combination.

1. Small peptides to stimulate rapid osteoblast infiltration and bone growth, suitable for use and delivery with nanostructured materials.
2. Nanostructured resorbable biomaterials made from novel helical rosette nanotubes, nanosurfaced polymers and nanosurfaced polymer and nanoscale ceramic composites. All of Nanovis’ biomaterials have demonstrated superior bone and soft tissue induction, polyetdesigned to accelerate and increase tissue infiltration, reduce inflammation, reduce bacterial colonization and deliver small molecules and peptide therapeutics.
3. Nanostructured implant surfaces and coatings designed to accelerate and increase tissue infiltration, reduce inflammation, and reduce bacterial colonization and deliver small molecules and peptide therapeutics

Product Pipeline Overview

Increased osteoblast growth in the presence of KRSR functionalized on HNPs (hydroxyapatite nanoparticles) compared to corresponding conventional HP (hydroxyapatite, or micron, particles).